Full name: ubiquitin conjugating enzyme E2 E1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: UBCH6

Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Expression: Ubiquitous expression in lymph node (RPKM 26.5), brain (RPKM 25.3) and 25 other tissues

Gene size: 85686bp

Exon count: 7