Full name: TNF receptor superfamily member 4

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: ACT35; CD134; IMD16; OX40; TXGP1L

Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]

Expression: Broad expression in fat (RPKM 2.7), lymph node (RPKM 1.6) and 14 other tissues

Gene size: 2814bp

Exon count: 6