Full name: GDP-L-fucose synthase

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: FX; P35B; SDR4E1; TSTA3

Summary: Tissue specific transplantation antigen P35B is a NADP(H)-binding protein. It catalyze the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of several fucosyltransferases involved in the expression of many glycoconjugates, including blood group ABH antigens and developmental adhesion antigens. Mutations in this gene may cause leukocyte adhesion deficiency, type II. [provided by RefSeq, Jul 2008]

Expression: Ubiquitous expression in stomach (RPKM 48.7), skin (RPKM 31.8) and 25 other tissues

Gene size: 5431bp

Exon count: 12