Full name: translin

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: BCLF-1; C3PO; RCHF1; REHF-1; TBRBP; TRSLN

Summary: This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

Expression: Ubiquitous expression in testis (RPKM 26.5), brain (RPKM 20.8) and 25 other tissues

Gene size: 12203bp

Exon count: 6