Full name: nuclear receptor subfamily 2 group C member 2

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: TAK1; TR4

Summary: This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]

Expression: Ubiquitous expression in brain (RPKM 10.5), thyroid (RPKM 9.7) and 25 other tissues

Gene size: 101691bp

Exon count: 21