TPR translocated promoter region, nuclear basket protein [ Homo sapiens (human) ]
Source: NCBI Gene (ID 7175)
Source: NCBI Gene (ID 7175)
Symbol: TPR
Full name: translocated promoter region, nuclear basket protein
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Summary: This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in testis (RPKM 29.9), thyroid (RPKM 16.2) and 25 other tissues
Orthologs: mouse
Gene size: 63602bp
Exon count: 51