Full name: polyribonucleotide nucleotidyltransferase 1

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: 1200003F12Rik; Old35; PNPase; Pnptl1

Summary: Predicted to enable 3'-5'-exoribonuclease activity; RNA binding activity; and polyribonucleotide nucleotidyltransferase activity. Involved in mitochondrial mRNA catabolic process; mitochondrion morphogenesis; and regulation of cellular respiration. Located in mitochondrial intermembrane space. Is expressed in central nervous system and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 70 and combined oxidative phosphorylation deficiency 13. Orthologous to human PNPT1 (polyribonucleotide nucleotidyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Ubiquitous expression in liver E14 (RPKM 13.5), placenta adult (RPKM 11.3) and 26 other tissues

Gene size: 31775bp

Exon count: 29