Full name: tryptophan hydroxylase 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: TPRH; TRPH

Summary: This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009]

Expression: Biased expression in stomach (RPKM 7.1), colon (RPKM 5.4) and 7 other tissues

Gene size: 28715bp

Exon count: 11