Full name: vacuolar protein sorting 72 homolog

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: CFL1; Swc2; TCFL1; YL-1; YL1

Summary: The protein encoded by this gene is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA break repair and apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. This protein may be responsible for binding H2AFZ, which has a role in chromosome segregation. This protein may also have a role in regulating long-term hematopoietic stem cell activity. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

Expression: Ubiquitous expression in brain (RPKM 14.7), prostate (RPKM 14.0) and 25 other tissues

Gene size: 13894bp

Exon count: 6