Full name: elongin A

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: SIII; SIII p110; TCEB3; TCEB3A

Summary: This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. [provided by RefSeq, Jul 2008]

Expression: Ubiquitous expression in lung (RPKM 15.9), thyroid (RPKM 14.1) and 25 other tissues

Gene size: 18589bp

Exon count: 11