Full name: serine/threonine kinase 4

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: KRS2; MST1; YSK3

Summary: The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]

Expression: Broad expression in lymph node (RPKM 17.1), appendix (RPKM 14.6) and 24 other tissues

Gene size: 113510bp

Exon count: 15