Full name: Spi-1 proto-oncogene

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: AGM10; OF; PU.1; SFPI1; SPI-1; SPI-A

Summary: This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Expression: Broad expression in bone marrow (RPKM 36.5), appendix (RPKM 27.0) and 18 other tissues

Gene size: 40748bp

Exon count: 8