Full name: Sp1 transcription factor

Gene type: protein coding

RefSeq status: REVIEWED

Summary: The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]

Expression: Ubiquitous expression in skin (RPKM 18.2), endometrium (RPKM 16.6) and 25 other tissues

Gene size: 36271bp

Exon count: 7