SIGLEC1 sialic acid binding Ig like lectin 1 [ Homo sapiens (human) ] - Gene - Data resources

6614

SIGLEC1 sialic acid binding Ig like lectin 1 [ Homo sapiens (human) ]
Source: NCBI Gene (ID 6614)

Symbol: SIGLEC1

Full name: sialic acid binding Ig like lectin 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: CD169; SIGLEC-1; SN

Summary: This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. The protein plays an important role in multiple human diseases and bacterial and viral infections has been shown to enhance SARS-CoV-2 infection. [provided by RefSeq, Dec 2021]

Expression: Broad expression in placenta (RPKM 8.2), spleen (RPKM 6.4) and 20 other tissues

Orthologs: mouse

Gene size: 25631bp

Exon count: 22