Full name: C-type lectin domain containing 7A

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: BGR; CANDF4; CD369; CLECSF12; DECTIN1; SCARE2

Summary: This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]

Expression: Broad expression in appendix (RPKM 22.1), bone marrow (RPKM 11.8) and 17 other tissues

Gene size: 13528bp

Exon count: 9