ECSCR endothelial cell surface expressed chemotaxis and apoptosis regulator [ Homo sapiens (human) ]
Source: NCBI Gene (ID 641700)
Source: NCBI Gene (ID 641700)
Symbol: ECSCR
Full name: endothelial cell surface expressed chemotaxis and apoptosis regulator
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Also known as: ARIA; ECSM2
Summary: The protein encoded by this gene is primarily found in endothelial cells and blood vessels, where it is involved in cell shape changes and EGF-induced cell migration. It can enhance the activation of vascular endothelial growth factor receptor-2/kinase insert domain receptor and also promote the proteolysis of internalized kinase insert domain receptor. This gene may play a role in angiogenesis-related diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Expression: Broad expression in placenta (RPKM 24.9), lung (RPKM 23.6) and 22 other tissues
Orthologs: mouse
Gene size: 14184bp
Exon count: 11