Full name: selectin E

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: CD62E; ELAM; ELAM1; ESEL; LECAM2; selectin-e

Summary: The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008]

Expression: Biased expression in prostate (RPKM 16.5), urinary bladder (RPKM 15.5) and 12 other tissues

Gene size: 11440bp

Exon count: 14