Full name: transient receptor potential cation channel, subfamily V, member 4

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: 0610033B08Rik; OTRPC4; Trp12; VR-OAC; VRL-2; VROAC

Summary: Enables several functions, including SH2 domain binding activity; calcium channel activity; and osmosensor activity. Involved in several processes, including cellular hypotonic salinity response; positive regulation of MAPK cascade; and positive regulation of cytokine production. Acts upstream of or within several processes, including hyperosmotic salinity response; osmosensory signaling pathway; and vasopressin secretion. Located in adherens junction; cilium; and plasma membrane. Is expressed in several structures, including autopod; brain; respiratory system; sensory organ; and skeleton. Used to study autosomal dominant nonsyndromic deafness 25. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2C; motor neuron disease (multiple); osteochondrodysplasia (multiple); and osteonecrosis. Orthologous to human TRPV4 (transient receptor potential cation channel subfamily V member 4). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Biased expression in kidney adult (RPKM 53.0), bladder adult (RPKM 22.4) and 7 other tissues

Gene size: 36285bp

Exon count: 16