Full name: C-X-C motif chemokine ligand 12

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: IRH; PBSF; SCYB12; SDF1; TLSF; TPAR1

Summary: This antimicrobial gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

Expression: Broad expression in endometrium (RPKM 50.4), spleen (RPKM 44.2) and 23 other tissues

Gene size: 14933bp

Exon count: 6