Full name: S100 calcium binding protein A1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: S100; S100-alpha; S100A

Summary: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. [provided by RefSeq, Jul 2008]

Expression: Biased expression in heart (RPKM 773.3), salivary gland (RPKM 114.1) and 3 other tissues

Gene size: 3606bp

Exon count: 3