Full name: RE1 silencing transcription factor

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: DFNA27; GINGF5; HGF5; NRSF; WT6; XBR

Summary: This gene was initially identified as a transcriptional repressor that represses neuronal genes in non-neuronal tissues. However, depending on the cellular context, this gene can act as either an oncogene or a tumor suppressor. The encoded protein is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regulator of neurogenesis. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2018]

Expression: Ubiquitous expression in bone marrow (RPKM 9.2), testis (RPKM 8.5) and 25 other tissues

Gene size: 27945bp

Exon count: 5