Full name: BCL2 related protein A1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: ACC-1; ACC-2; ACC1; ACC2; BCL2L5; BFL1; GRS; HBPA1

Summary: This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Expression: Biased expression in bone marrow (RPKM 133.6), appendix (RPKM 46.2) and 4 other tissues

Gene size: 10305bp

Exon count: 3