Full name: Rac family small GTPase 2

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: EN-7; Gx; HSPC022; IMD73A; IMD73B; IMD73C; p21-Rac2

Summary: This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6. [provided by RefSeq, Jul 2013]

Expression: Biased expression in lymph node (RPKM 157.7), bone marrow (RPKM 130.6) and 9 other tissues

Gene size: 19000bp

Exon count: 8