Full name: protein tyrosine phosphatase receptor type M

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: PTPRL1; R-PTP-MU; RPTPM; RPTPU; hR-PTPu

Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Expression: Broad expression in fat (RPKM 28.8), thyroid (RPKM 25.6) and 23 other tissues

Gene size: 839541bp

Exon count: 40