Full name: regulatory associated protein of MTOR complex 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: KOG1; Mip1

Summary: This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Expression: Ubiquitous expression in brain (RPKM 5.6), testis (RPKM 4.5) and 25 other tissues

Gene size: 421531bp

Exon count: 34