Full name: BAG cochaperone 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: BAG-1; HAP; RAP46

Summary: The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X. [provided by RefSeq, Feb 2010]

Expression: Ubiquitous expression in kidney (RPKM 19.7), colon (RPKM 18.5) and 25 other tissues

Gene size: 12238bp

Exon count: 7