ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B [ Homo sapiens (human) ]
Source: NCBI Gene (ID 56899)
Source: NCBI Gene (ID 56899)
Symbol: ANKS1B
Full name: ankyrin repeat and sterile alpha motif domain containing 1B
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Also known as: AIDA; AIDA-1; ANKS2; EB-1; EB1; cajalin-2
Summary: This gene encodes a multi-domain protein that is predominantly expressed in brain and testis. This protein interacts with amyloid beta protein precursor (AbetaPP) and may have a role in normal brain development, and in the pathogenesis of Alzheimer's disease. Expression of this gene has been shown to be elevated in patients with pre-B cell acute lymphocytic leukemia associated with t(1;19) translocation. Alternatively spliced transcript variants encoding different isoforms (some with different subcellular localization, PMID:15004329) have been described for this gene. [provided by RefSeq, Aug 2011]
Expression: Broad expression in brain (RPKM 8.0), thyroid (RPKM 1.1) and 21 other tissues
Orthologs: mouse
Gene size: 1250151bp
Exon count: 39