Full name: serine protease 8

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: CAP1; PROSTASIN

Summary: This gene encodes a member of the peptidase S1 or chymotrypsin family of serine proteases. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate via a disulfide bond to form the heterodimeric enzyme. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. This protease exhibits trypsin-like substrate specificity, cleaving protein substrates at the carboxyl terminus of lysine or arginine residues. The encoded protease partially mediates proteolytic activation of the epithelial sodium channel, a regulator of sodium balance, and may also play a role in epithelial barrier formation. [provided by RefSeq, Feb 2016]

Expression: Broad expression in small intestine (RPKM 73.7), colon (RPKM 73.6) and 14 other tissues

Gene size: 4295bp

Exon count: 6