Full name: thioredoxin related transmembrane protein 4

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: DJ971N18.2; PDIA14; TXNDC13

Summary: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane domain and C-terminal ASP/GLU-rich calcium binding domain. Unlike most members of this gene family, it lacks a C-terminal ER-retention sequence. The encoded protein has been shown to have reductase activity in vitro. [provided by RefSeq, Jan 2017]

Expression: Broad expression in testis (RPKM 50.0), heart (RPKM 24.6) and 24 other tissues

Gene size: 42416bp

Exon count: 8