Full name: protein associated with LIN7 1, MAGUK family member

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: 3830420B02Rik; Mpp5

Summary: Predicted to enable guanylate kinase activity and protein domain specific binding activity. Involved in nervous system development; protein localization to myelin sheath abaxonal region; and regulation of transforming growth factor beta receptor signaling pathway. Acts upstream of or within cellular protein localization; gene expression; and plasma membrane organization. Located in several cellular components, including Schmidt-Lanterman incisure; lateral loop; and myelin sheath adaxonal region. Is expressed in several structures, including cerebral cortex; early conceptus; eye; and future spinal cord neural plate. Used to study Leber congenital amaurosis. Orthologous to human PALS1 (protein associated with LIN7 1, MAGUK p55 family member). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Ubiquitous expression in placenta adult (RPKM 4.8), CNS E11.5 (RPKM 4.1) and 24 other tissues

Gene size: 91883bp

Exon count: 16