Full name: coiled-coil domain containing 88A

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212; PEHO; PEHOL

Summary: This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Expression: Broad expression in testis (RPKM 20.8), brain (RPKM 15.3) and 23 other tissues

Gene size: 132015bp

Exon count: 34