FRMD4A FERM domain containing 4A [ Homo sapiens (human) ] - Gene - Data resources

55691

FRMD4A FERM domain containing 4A [ Homo sapiens (human) ]
Source: NCBI Gene (ID 55691)

Symbol: FRMD4A

Full name: FERM domain containing 4A

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: CCAFCA; FRMD4; bA295P9.4

Summary: This gene encodes a FERM domain-containing protein that regulates epithelial cell polarity. It connects ADP ribosylation factor 6 (ARF6) with the Par protein complex, which regulates the remodeling of adherens junctions and linear actin cable formation during epithelial cell polarization. Polymorphisms in this gene are associated with Alzheimer's disease, and also with nicotine dependence. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Expression: Ubiquitous expression in fat (RPKM 10.5), skin (RPKM 7.3) and 25 other tissues

Orthologs: mouse

Gene size: 687219bp

Exon count: 30