Full name: SCY1 like pseudokinase 2

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: AMC4; AMCNACC; CVAK104

Summary: The protein encoded by this gene associates with clathrin-coated complexes at the plasma membrane and with endocytic coated vesicles. The encoded protein phosphorylates the beta2 subunit of the plasma membrane adapter complex AP2 and interacts with clathrin, showing involvement in clathrin-dependent pathways between the trans-Golgi network and the endosomal system. In addition, this protein has a role in the Wnt signaling pathway by targeting frizzled 5 (Fzd5) for lysosomal degradation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]

Expression: Ubiquitous expression in colon (RPKM 12.7), esophagus (RPKM 10.5) and 25 other tissues

Gene size: 74539bp

Exon count: 20