Full name: threonine synthase like 2

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: SOFAT; THS2; TSH2

Summary: This gene encodes a threonine synthase-like protein. A similar enzyme in mouse can catalyze the degradation of O-phospho-homoserine to a-ketobutyrate, phosphate, and ammonia. This protein also has phospho-lyase activity on both gamma and beta phosphorylated substrates. In mouse an alternatively spliced form of this protein has been shown to act as a cytokine and can induce the production of the inflammatory cytokine IL6 in osteoblasts. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

Expression: Ubiquitous expression in kidney (RPKM 9.9), thyroid (RPKM 9.5) and 24 other tissues

Gene size: 16282bp

Exon count: 9