Full name: protein phosphatase 2 scaffold subunit Abeta

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: PP2A-Abeta; PR65B

Summary: This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

Expression: Ubiquitous expression in testis (RPKM 13.7), fat (RPKM 13.4) and 25 other tissues

Gene size: 78390bp

Exon count: 21