Full name: protein phosphatase 1 regulatory subunit 3C

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: PPP1R5; PTG

Summary: This gene encodes a carbohydrate binding protein that is a subunit of the protein phosphatase 1 (PP1) complex. PP1 catalyzes reversible protein phosphorylation, which is important in a wide range of cellular activities. The encoded protein affects glycogen biosynthesis by activating glycogen synthase and limiting glycogen breakdown by reducing glycogen phosphorylase activity. DNA hypermethylation of this gene has been found in colorectal cancer patients. The encoded protein also interacts with the laforin protein, which is a protein tyrosine phosphatase implicated in Lafora disease. [provided by RefSeq, Sep 2016]

Expression: Broad expression in heart (RPKM 69.5), esophagus (RPKM 32.0) and 14 other tissues

Gene size: 4630bp

Exon count: 2