Full name: cell adhesion molecule 1

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: 2900073G06Rik; 3100001I08Rik; Bl2; Igsf4; Igsf4a; Necl2; RA175; RA175A; RA175B; RA175C; RA175N; ST17; SgIGSF; SynCam; Tslc1

Summary: Enables PDZ domain binding activity; protein homodimerization activity; and signaling receptor binding activity. Involved in several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homophilic cell adhesion via plasma membrane adhesion molecules; and synapse organization. Acts upstream of or within bone development; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; and unidimensional cell growth. Located in several cellular components, including basolateral plasma membrane; cell body fiber; and varicosity. Is integral component of postsynaptic membrane. Is active in Schaffer collateral - CA1 synapse. Is integral component of presynaptic membrane. Is expressed in several structures, including nervous system; respiratory system; sensory organ; tooth; and urinary system. Human ortholog(s) of this gene implicated in breast carcinoma and prostate cancer. Orthologous to human CADM1 (cell adhesion molecule 1). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Broad expression in CNS E18 (RPKM 13.0), CNS E14 (RPKM 8.1) and 15 other tissues

Gene size: 332111bp

Exon count: 19