Full name: DNA polymerase delta 2, accessory subunit

Gene type: protein coding

RefSeq status: REVIEWED

Summary: This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Mar 2012]

Expression: Ubiquitous expression in heart (RPKM 20.0), ovary (RPKM 19.1) and 25 other tissues

Gene size: 9646bp

Exon count: 15