Full name: phospholipase A2 group V

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: FRFB; GV-PLA2; PLA2-10; hVPLA(2)

Summary: This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

Expression: Biased expression in heart (RPKM 14.5), ovary (RPKM 8.6) and 8 other tissues

Gene size: 63504bp

Exon count: 13