Full name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: IPFK2; PFK2; iPFK-2

Summary: The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]

Expression: Biased expression in fat (RPKM 188.2), bone marrow (RPKM 67.0) and 9 other tissues

Gene size: 181717bp

Exon count: 21