Full name: proenkephalin

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: PE; PENK-A

Summary: This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the pentapeptide opioids Met-enkephalin and Leu-enkephalin, which are stored in synaptic vesicles, then released into the synapse where they bind to mu- and delta-opioid receptors to modulate the perception of pain. Other non-opioid cleavage products may function in distinct biological activities. [provided by RefSeq, Jul 2015]

Expression: Biased expression in adrenal (RPKM 200.5), testis (RPKM 60.4) and 1 other tissue

Gene size: 5685bp

Exon count: 4