Full name: phosphodiesterase 4B

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: DPDE4; PDEIVB

Summary: This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

Expression: Broad expression in bone marrow (RPKM 18.7), brain (RPKM 17.6) and 22 other tissues

Gene size: 582070bp

Exon count: 25