Full name: phosphodiesterase 4B, cAMP specific

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: Dpde4; dunce

Summary: Enables 3',5'-cyclic-AMP phosphodiesterase activity; gamma-tubulin binding activity; and transmembrane transporter binding activity. Involved in several processes, including cellular response to epinephrine stimulus; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process; and regulation of muscle system process. Acts upstream of or within several processes, including cellular response to lipopolysaccharide; neutrophil chemotaxis; and neutrophil homeostasis. Located in several cellular components, including Z disc; centrosome; and synaptic vesicle. Part of gamma-tubulin complex and voltage-gated calcium channel complex. Is expressed in several structures, including alimentary system; ear; genitourinary system; nervous system; and respiratory system. Orthologous to human PDE4B (phosphodiesterase 4B). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Broad expression in cortex adult (RPKM 9.7), frontal lobe adult (RPKM 9.3) and 25 other tissues

Gene size: 519944bp

Exon count: 25