Full name: actin like 6B

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: ACTL6; BAF53B; DEE76; EIEE76; IDDSSAD; SMARCN2; arpNalpha

Summary: The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a subunit of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. This subunit may be involved in the regulation of genes by structural modulation of their chromatin, specifically in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Expression: Biased expression in brain (RPKM 15.4) and adrenal (RPKM 1.2)

Gene size: 13352bp

Exon count: 14