Full name: phosphodiesterase 1C

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: DFNA74; Hcam3; cam-PDE 1C; hCam-3

Summary: This gene encodes an enzyme that belongs to the 3'5'-cyclic nucleotide phosphodiesterase family. Members of this family catalyze hydrolysis of the cyclic nucleotides, cyclic adenosine monophosphate and cyclic guanosine monophosphate, to the corresponding nucleoside 5'-monophosphates. The enzyme encoded by this gene regulates proliferation and migration of vascular smooth muscle cells, and neointimal hyperplasia. This enzyme also plays a role in pathological vascular remodeling by regulating the stability of growth factor receptors, such as PDGF-receptor-beta. [provided by RefSeq, Jul 2016]

Expression: Biased expression in heart (RPKM 9.1), brain (RPKM 4.0) and 12 other tissues

Gene size: 811448bp

Exon count: 35