Full name: VRK serine/threonine kinase 3

Gene type: protein coding

RefSeq status: REVIEWED

Summary: This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. In both human and mouse, this gene has substitutions at several residues within the ATP binding motifs that in other kinases have been shown to be required for catalysis. In vitro assays indicate the protein lacks phosphorylation activity. The protein, however, likely retains its substrate binding capability. This gene is widely expressed in human tissues and its protein localizes to the nucleus. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]

Expression: Broad expression in testis (RPKM 36.5), small intestine (RPKM 9.1) and 24 other tissues

Gene size: 48905bp

Exon count: 18