Full name: COP9 signalosome subunit 4

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: CSN4; SGN4

Summary: This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Expression: Ubiquitous expression in testis (RPKM 26.4), brain (RPKM 21.8) and 25 other tissues

Gene size: 40636bp

Exon count: 11