Full name: phosphodiesterase 11A

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: PPNAD2

Summary: The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Expression: Biased expression in prostate (RPKM 3.1), fat (RPKM 1.5) and 11 other tissues

Gene size: 485096bp

Exon count: 24