Full name: 2'-5'-oligoadenylate synthetase 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: E18/E16; IFI-4; IMD100; OIAS; OIASI

Summary: This interferon-induced gene encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As). This protein plays a key role in innate cellular antiviral response, and has been implicated in other cellular processes like cell growth and apoptosis. Alternative splicing results in multiple transcript variants with different enzymatic activities. Polymorphisms in this gene have been associated with susceptibility to viral infection, including SARS-CoV-2, and diabetes mellitus, type 1. This gene is located in a cluster of related genes on chromosome 12. [provided by RefSeq, May 2022]

Expression: Ubiquitous expression in spleen (RPKM 18.0), colon (RPKM 15.8) and 24 other tissues

Gene size: 26258bp

Exon count: 7