Full name: nucleoporin 88

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: FADS4

Summary: The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

Expression: Ubiquitous expression in testis (RPKM 25.7), lymph node (RPKM 15.5) and 25 other tissues

Gene size: 34830bp

Exon count: 18